Journal article
Association of hormonal and reproductive factors with differentiated thyroid cancer risk in women: a pooled prospective cohort analysis
TJ O’Grady, S Rinaldi, KA Michels, HO Adami, JE Buring, Y Chen, TV Clendenen, A D’Aloisio, JC DeHart, S Franceschi, ND Freedman, GL Gierach, GG Giles, JV Lacey, IM Lee, LM Liao, MS Linet, ML McCullough, AV Patel, A Prizment Show all
International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2024
DOI: 10.1093/ije/dyad172
Abstract
Background: The incidence of differentiated thyroid cancer (DTC) is higher in women than in men but whether sex steroid hormones contribute to this difference remains unclear. Studies of reproductive and hormonal factors and thyroid cancer risk have provided inconsistent results. Methods: Original data from 1 252 907 women in 16 cohorts in North America, Europe, Australia and Asia were combined to evaluate associations of DTC risk with reproductive and hormonal factors. Multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% CIs. Results: During follow-up, 2142 women were diagnosed with DTC. Factors associated with higher risk of DTC included y..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the Intramural Research Program of the US National Cancer Institute, National Institutes of Health. Cohort-specific funding is described in the Acknowledgements